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October - 2018

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Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial

R.P. Dellinger, S.M.Bagshaw, M Antonelli, et al for the EUPHRATES Trials Investigators JAMA, 2018, 320(14):1455-1463


We all know endotoxin is a problem - it activates the inflammatory response, leads to systemic damage external to primary infection sites, and can be hard to turn off. 

We have tried to modify this and failed - monoclonal human and mouse antibody, recombinant bacterial...


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