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August - 2022

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Showing Journal 4 of 4

Effect of High- vs Low-Dose Tranexamic Acid Infusion on Need for Red Blood Cell Transfusion and Adverse Events in Patients Undergoing Cardiac Surgery. The OPTIMAL Randomized Clinical Trial

J Shi, C Zhou, W Pan et al for the OPTIMAL Study Group JAMA, 2022, 328(4):336-347


Tranexamic acid is the mainstay antifibrinolytic agent used to reduce blood loss after cardiac surgery. However there are ongoing concerns regarding associated seizures (increased risk of seizure, stroke, death at 1-year with single dose of 50 or 100 mg/kg in...


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