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April - 2023

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Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion

P Bouzat, J Charbit, P-S Abback, et al for the PROCOAG Study Group JAMA, 2023, online first


Mortality among patients with trauma and bleeding remains high. Trauma induced coagulopathy contributes to this, and strategies such as tranexamic acid (TXA), reduction of fluid expansion, high-ratio blood product transfusion, and expedient hemorrhage control have improved some...


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