March - 2011
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A Randomized Clinical Trial of Hydroxymethylglutaryl Coenzyme A Reductase Inhibition for Acute Lung Injury (The HARP Study)Thelma R. Craig, Martin J. Duffy, Murali Shyamsundar, Cliona McDowell, Cecilia M. O'Kane, J. Stuart Elborn, and Daniel F. McAuley Am Journ of Resp and Crit Care Med, 2011, 183(5):620-626 This page is only available to Crit-IQ subscribers. To view the rest of this review and gain access to our vast array of critical care teaching tools including podcasts, vodcasts, modules, exam preparation tools, teaching aids and much more, login here, or Become a Member to register |
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A prospective, db, phase 2, RCT of patients with ARDS ventilated for >24 hrs, comparing simvastatin 80mg to placebo reports no difference in primary outcome (lung water), but a reduction in organ dysfunction and BAL Il-8 in the treatment groups. The authors conclude simvastatin is...