May - 2012
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Drotrecogin Alfa (Activated) in Adults with Septic ShockPROWESS-SHOCK Study Group NEJM, 2012, May 22, 2012 (10.1056/NEJMoa1202290) This page is only available to Crit-IQ subscribers. To view the rest of this review and gain access to our vast array of critical care teaching tools including podcasts, vodcasts, modules, exam preparation tools, teaching aids and much more, login here, or Become a Member to register |
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In this well conducted, multicentre international RCT of APC vs placebo in 1600 critically ill patients with septic shock requiring Noradrenaline (minimum 5 mcg/min, average >20 mcg/min at entry) or equivalent vasopressor, there was no difference in 28-day or 90-day mortality,...