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January - 2013

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Effect of Intravenous Paracetamol on Postoperative Morphine Requirements in Neonates and Infants Undergoing Major Noncardiac Surgery: A Randomized Controlled Trial

lse Ceelie, Saskia N. de Wildt, Monique van Dijk, et al JAMA, 2013, 309(2):149-154

Comment

This RCT conducted in 74 infants requiring major thoracic (non-cardiac) or abdominal surgery compared IV paracetamol to IV morphine as primary analgesic agent, with rescue morphine for both. 

They found the paracetamol group received less morphine  (median 121 ug/kg vs...


January



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