Journal Club - Recent Additions

April - 2014

Previous Next    

Showing Journal 10 of 15


Fibrinolysis for Patients with Intermediate-Risk Pulmonary Embolism

the PEITHO Investigators NEJM, 2014, 370:1402-1411

Comment

The decision about whether or not to thrombolyse the “intermediate-risk” PE remains difficult. In the past 40 years there have been fewer than 1000 patients enrolled in RCTs of heparin vs lysis for PE?

This multi-center prospective RCT tries...


April



Previous Comments

For crying out aloud will someone please follow up the respiratory function and health related quality of life on these patients. Of course mortality was no different, it's too rare.
Motown Philippe-13 Apr, 2014 11:49:55 AM

Amen Motown.
LTC-16 Apr, 2014 09:50:11 AM

It never got much attention... but the MOPETT trial in 2012 showed an 40%ARR in pulmonary hypertension at 6 months (15% in thrombolysis and 50% in anticoagulation alone). They also looked at functional status and those thrombolysed had much better function. I'm not sure why it never received attention from the critical care world - published in the american journal of cardiology? only had half dose thrombolysis? high prevalence of pulmonary hypertension at 6 months? Anyway - I thought is was well worth repeating as in terms of symptom control at 6 months it definitely go my attention.
Cynthia-16 Jul, 2014 05:38:09 PM