Journal Club - Recent Additions

September - 2016

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Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock -A Randomized Clinical Trial

F Bloos, E Trips, A Nierhaus, et al for SepNet Critical Care Trials Group JAMA Int Med, 2016, 176(9);1266-1276


This prospect 2x2 factorial RCT investigates the effect of high-dose sodium selenite and PCT guided therapy on outcomes in severe sepsis. Selenium has been proposed as adjunctive sepsis therapy since it restores activity of glutathione peroxidase, attenuates oxidative...


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