05:05 PM May 29th
JAMA COBI RCT continuous infusion 20% hypertonic saline vs standard care for minimum 48 hours in moderate to severe TBI = no difference neurological outcome 6 months. Intervention associated lower risk intracranial hypertension for 1st 2-days, followed by rebound ICH, apparent after cessation of therapy.
05:05 PM May 12th
JAMA MIS-C - Observational study of combined treatment with IVIG + methylprednisolone vs IVIG alone associated with reduced treatment failure, new LV dysfunction, hemodynamic support, and PICU LOS better course of fever in children with MIS-C.
02:05 PM May 11th
JAMA REALITY - Restrictive transfusion strategy compared with a liberal strategy resulted in a noninferior rate of major cardiovascular events among patients with acute myocardial infarction and anemia.
07:05 PM May 10th
NEJM CONFIRM terlipressin with albumin more effective than albumin alone at reversing hepatorenal syndrome in adults with cirrhosis and HRS-1. Interesting cautionary discussion about terlipressin association with more serious adverse events, particularly respiratory failure..
04:05 PM May 10th
NEJM COVACTA adults hospitalised with COVID-19 pneumonia, use of tocilizumab was not assicated with difference in clinical status at day 28, or secondary outcomes. Signal of difference in hospital LOS, ICU LOS, ventilator free days favoured tocilizumab.