Recent News

  • 09:09 AM Sep 7th
    NEJM BOX Trial: Use of restrictive (PaO2 68-75 mmHg) vs liberal (PaO2 98-105 mmHg) oxygenation target in comatose survivors of OHCA requiring mechanical ventilation not associated with difference in 90-d death or severe disability (32 vs 34%, p=0.69)
  • 09:09 AM Sep 7th
    NEJM BOX Trial -  the use of a high vs low blood pressure target in comatose survivors of OHCA requiring mechanical ventilation was not associated with difference in 90-d death or severe disability. 
  • 04:07 PM Jul 31st
    JAMA OPTIMAL Trial - High vs low dose infusion TXA for adults undergoing cardiac surgery with bypass associated modest, significant decrease red cell transfusion proportion, and non-inferiority for composite 30-day mortality, seizure, renal dysfunction and thrombotic events. Proportion post-operative seizures in secondary and post-hoc analysis requires further consideration.
  • 12:06 PM Jun 28th
    JAMA NITRIC Trial: Among 1371 infants undergoing congenital heart surgery requiring CPB, delivery of nitric oxide into the CPB did not increase ventilator-free survival censored at 28 days. No benefit in secondary outcomes or subgroups was observed, including subgroup of children less than 6-weeks.
  • 10:06 AM Jun 28th
    JAMA Viewpoint: Surrogate decision-making is difficult. Respecting the authenticity and sovereignty of advance care directives,. Juggling these with the emotional burden of conflicting family morals during substituted judgement. Wendler expertly provides us the hierarchy of values for autonomy in treatment decision-making - non-intrusion, sovereignty, authenticity, best interest, moral standing - and urges us to consider them in our care. 

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