07:02 AM Feb 19th
JAMA RCT does not support use of single high dose oral vitamin D3 for treatment of moderate to severe COVID-19 in hospitalized patients. Limitations in design, however, confirms lack of benefit reported in multiple large non-COVID trials in hospital or ICU patients (VIOLET, VITdAL-ICU)
09:02 AM Feb 14th
NEJM DePPaRT: 1% of patients with loss of cardiac activity after planned withdrawal of life sustaining therapy have transient resumption of cardiac activity observable by bedside reports and corroborated by ECG and IABP waveform activity. Retrospective waveform review showed resumption of cardiac activity in 14% of patients. The longest period of pulselessness that was followed by resumption of cardiac activity was 4 minutes 20 seconds.
08:02 AM Feb 14th
JAMA OHCA sodium nitrite: Paramedic administration of 45mg or 60 mg sodium nitrite to patients with OHCA, vs placebo, did not improve survival to hospital admission, or secondary outcomes including survival or neurological recovery in 1502 adults in Seattle.King County. These findings do not support the use of sodium nitrite during resuscitation from out-of-hospital cardiac arrest.
06:02 PM Feb 13th
NEJM: Dexmedetomidine vs Propofol for light-sedation in mechanically ventilated adults with sepsis, outcomes did not differ between.
06:02 PM Feb 12th
NEJM HOT-ICU Trial 2928 adults in ICU with acute hypoxaemic respiratory failure (mean P:F 118), an oxygen target of PaO2 60 mmHg vs 90 mmHg did not result in lower 90-d mortality, or secondary outcomes including mesenteric ischaemia and HIE