September - 2012
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Activated protein C and septic shock: A propensity-matched cohort studyThe Co-operative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group Crit Care Med, 2012, 28 August 2012, publish ahead of print, doi: 10.10 This page is only available to Crit-IQ subscribers. To view the rest of this review and gain access to our vast array of critical care teaching tools including podcasts, vodcasts, modules, exam preparation tools, teaching aids and much more, login here, or Become a Member to register |
September |
Previous Comments
| If we are concerned about the 90 day outcomes, then many of the patients being treated on ICU should not be treated. Though the studies have proven otherwise, when used in the right settings and sensibly,rAPC did wonders. Nothing else can explain the dramatic decline in the need for vasopressors when rAPC was used. To be a convert one would have had to use rAPC in the setting of rapidly increasing need for vasopressors and refractory shock. Unfortunately for those disbelievers and for those who jump the EBM bandwagon of randomised controlled trials, they have now lost the valuable chance of experiencing the beneficial effects of rAPC in refractory septic shock. | |
| sceptic-17 Sep, 2012 11:20:44 PM | |
Comment
We should all be familiar with the history of rAPC in ICU. If your memory is hazy the authors remind us in the introduction;
2001 - PROWESS reports 6.1% decrease in 28-day mortality for septic shock with rAPC vs placebo.
2004 - No difference in 90-day mortality for PROWESS...