Journal Club - Recent Additions

December - 2012

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Diaphragm Muscle Thinning in Patients Who Are Mechanically Ventilated

H Grosu, Y Lee, J Lee, et al Chest, 2012, 142(6);1455-1460

Comment

The authors start by telling us that difficulty weaning occurs in 20-25% of patients, with 40% of ICU time devoted to weaning from MV. Ventilator induced diaphragm dysfunction (VIDD),  a loss of force generation due to MV, may contribute. In this study, 7 newly intubated patients in a...


December



Previous Comments

I find this very interesting, albeit with small numbers. Fits nicely with previous work suggesting that once the diaphragm is fatigued, it can take more than 24 hours for it to recover in long term weaning patients.
Todd Fraser-30 Dec, 2012 09:49:43 AM

simple principle/facts with profound implications. How refreshing to see such studies. Well done!
very pleased!-03 Jan, 2013 10:54:13 PM

The fact is interesting from clinical point of view. One important thing to consider is whether this thinning of the diaphragm is simply because of disuse atrophy or there is an element of catabolic and nutritional process compounding it. Moreover do all diseases have the same effect in thinning the muscle or the septic cases have more of such incidences. Definitely the underlying cause for which the patient was ventilated and paralyzed may deviate the natural history of such incidences and modify our approach to such problems.
Dr. Prashant Kumar, India-05 Jan, 2013 04:56:55 AM