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December - 2015

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A Multicenter Randomized Trial of Continuous versus Intermittent B-Lactam Infusion in Severe Sepsis

J Delahunty, J Roberts, J Davis, et al for the BLING II Investigators for the ANZICS Clinical Trials Group Am J Resp Crit Care Med, 2015, 192 (11); 1298-1305

Comment

The traditional administration of B-lactams in critical illness is by intermittent dosing. However the time-dependence of antibacterial activity, and animal and in vitro evidence of better bacterial killing through continuous infusion, has led to the...


December



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